Multi-scale X-ray phase-contrast tomography of the cochlea

Schaeper, Dr. Jannis Justus

dc.contributor.author	Schaeper, Dr. Jannis Justus
dc.date.accessioned	2025-12-05T09:47:04Z
dc.date.available	2025-12-05T09:47:04Z
dc.date.issued	2025	de
dc.identifier.uri	https://doi.org/10.17875/gup2025-2946
dc.format.extent	IX, 148	de
dc.format.medium	Print	de
dc.language.iso	eng	de
dc.relation.ispartofseries	Göttingen Series in X-ray Physics	de
dc.rights.uri	https://creativecommons.org/licenses/by-sa/4.0/deed.de
dc.subject.ddc	530	de
dc.subject.other	OAPEN	de
dc.title	Multi-scale X-ray phase-contrast tomography of the cochlea	de
dc.type	monograph	de
dc.price.print	44,00
dc.identifier.urn	urn:nbn:de:gbv:7-isbn-978-3-86395-677-6-7
dc.description.print	Softcover, 17x24	de
dc.subject.division	peerReviewed	de
dc.subject.subjectheading	Chemie	de
dc.relation.isbn-13	978-3-86395-677-6
dc.identifier.articlenumber	8102489	de
dc.identifier.intern	isbn-978-3-86395-677-6	de
dc.bibliographicCitation.volume	033	de
dc.type.subtype	thesis	de
dc.subject.bisac	SCI055000	de
dc.subject.vlb	640	de
dc.subject.bic	PH	de
dc.description.abstracteng	The organ of Corti in the mammalian cochlea is the receptor organ for hearing, transducing sound into auditory nerve signals. In order to further extend our understanding of the underlying neurophysiology, three dimenstional (3D) imaging capabilities are required that are able to quantify the micro-anatomy of the cochlea. Due to the subtle and intricate structure of the cochlea, a non-destructive imaging method such as 3D virtual histology by propagation-based X-ray phase-contrast computed tomography (XPCT) is preferred. This thesis investigates the structure of the mammalian cochlea of different animal models and humans with XPCT. The scales covered range from mm-sized tissue segments up to small-animal heads and the human temporal bone. Experiments have been performed at dedicated imaging beamlines at synchrotron radiation facilities and at in-house laboratory µ-CT setups, exploring sample embedding and staining protocols. Datasets in this thesis include the visualisation of noise-induced hearing loss in the guinea pig, segmentation of spiral ganglion neuron nuclei and the visualization of the orientation of cochlear implants.	de
dc.subject.eng	3D virtual histology	de
dc.subject.eng	X-ray phase-contrast computed tomography	de
dc.subject.eng	synchrotron radiation	de
dc.subject.eng	mammalian cochlea	de
dc.subject.eng	cochlea implant	de
dc.notes.vlb-print	lieferbar
dc.intern.doi	10.17875/gup2025-2946	de
dc.identifier.purl	https://resolver.sub.uni-goettingen.de/purl?univerlag-isbn-978-3-86395-677-6
dc.format.chapters	-	de
dc.intern.asin	386395677x
dc.subject.thema	PH	de

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