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Synaptic vesicles studied by small-angle x-ray scattering

dc.contributor.authorCastorph, Simon
dc.date.accessioned2012-04-15T07:09:45Z
dc.date.available2014-04-15T07:09:45Z
dc.date.issued2012
dc.identifier.urihttps://doi.org/10.17875/gup2012-88
dc.format.extentVIII, 100
dc.format.mediumPrint
dc.language.isoger
dc.relation.ispartofseriesGöttingen Series in x-ray Physics
dc.rights.urihttp://creativecommons.org/licenses/by-nd/3.0/
dc.subject.ddc530
dc.titleSynaptic vesicles studied by small-angle x-ray scattering
dc.typemonograph
dc.price.print32,00
dc.identifier.urnurn:nbn:de:gbv:7-isbn-978-3-86395-097-2-0
dc.identifier.ppn736451536
dc.description.printSoftcover, 17x24
dc.subject.divisionpeerReviewed
dc.subject.subjectheadingPhysik
dc.relation.isbn-13978-3-86395-097-2
dc.relation.issn2191-9860
dc.identifier.articlenumber8101149
dc.identifier.internisbn-978-3-86395-097-2
dc.identifier.internisbn-978-3-86395-097-2
dc.bibliographicCitation.volume004
dc.type.subtypethesis
dc.subject.bisacSCI055000
dc.notes.oaiprint
dc.subject.vlb640
dc.subject.bicPH
dc.description.abstractengThe heterogeneous structure of synaptic vesicles isolated from rat brain is investigated considering solution small-angle x-ray scattering data in combination with data obtained by cryogenic electron microscopy, dynamic light scattering and biochemical analysis. Overall low resolution structural models of the entire functional synaptic vesicle are proposed, elucidating details on the density profile of the membrane, including contributions from the lipids and the proteins, as well as addressing the average conformation and overall lateral organization of proteins in micro-domains on the average synaptic vesicle under quasi-physiological conditions. Entropic contributions to free energy due to possible protein cluster formation and disintegration on the synaptic vesicle are investigated. Further, cell free fusion systems are characterized employing dynamic light scattering and applicability of small-angle x-ray scattering is considered for investigating membrane fusion processes.
dc.notes.vlb-printlieferbar
dc.intern.doi10.17875/gup2023-88
dc.identifier.purlhttp://resolver.sub.uni-goettingen.de/purl?isbn-978-3-86395-097-2
dc.identifier.asin3863950976
dc.subject.themaPH


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